Symbol
Name
ID

Mycn
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
MGI:97357

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Secondary microcephaly	Vocal cord paralysis	Intellectual disability	Intellectual disability, mild	Specific learning disability
Disease(s) Associated with MYCN
Feingold syndrome

Mouse Phenotypes

nervous system phenotype

abnormal neuron differentiation

premature neuronal precursor differentiation

abnormal neuronal precursor proliferation

abnormal neural tube morphology

abnormal embryonic neuroepithelium morphology

abnormal embryonic neuroepithelial layer differentiation

decreased embryonic neuroepithelium thickness

abnormal brain morphology

abnormal forebrain development

abnormal cortical ventricular zone morphology

abnormal cerebellum development

abnormal cerebellar foliation

abnormal cerebellum external granule cell layer morphology

decreased brain size

abnormal medulla oblongata morphology

abnormal cerebral cortex morphology

telencephalon hypoplasia

abnormal cerebellum morphology

abnormal cerebellar Purkinje cell layer

decreased Purkinje cell number

ectopic Purkinje cell

abnormal cerebellar granule layer morphology

abnormal cerebellar molecular layer

small cerebellum

decreased neuronal precursor cell number

abnormal cranial ganglia morphology

small trigeminal ganglion

disorganized dorsal root ganglion

small dorsal root ganglion

dorsal root ganglion hypoplasia

Availability

Mouse Genotype

Mycn^tm1Fwa/Mycn^tm1Fwa

Mycn^tm1Knd/Mycn^tm1Knd

Mycn^tm1Par/Mycn^tm1Par

Mycn^tm1Jrt/Mycn^tm1Par

Mycn^tm1Psk/Mycn^tm1Psk
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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